Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system.

Ciarra AlmeriaRené WeissMaike KeckViktoria WeberCornelia KasperDominik Egger

Published in: Biotechnology letters (2024)

The production of MSC-EVs in a 3D bioreactor system under hypoxic conditions resulted in increased EV concentration and purity. This system could be especially useful in screening culture conditions for the production of 3D-derived MSC-EVs.

Keyphrases

wastewater treatment
endothelial cells
stem cells
bone marrow
induced pluripotent stem cells