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Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study.

Thalia Shoshana FieldBob WeijsAntonio CurcioMichela GiustozziSaulius SudikasAnja KatholingChristopher WallenhorstJeffrey I WeitzAlexander T CohenCarlos Martinez
Published in: Thrombosis and haemostasis (2019)
 Our findings support the hypothesis that AF is a distinct risk factor for dementia, independent of stroke/TIA and other vascular risk factors. In those without stroke/TIA, risk of dementia is increased only in those who are not on anticoagulation, suggesting anticoagulation is protective presumably through reduction of sub-clinical embolic events. Further prospective research is needed to better ascertain the role of anticoagulation amongst targeted therapeutic strategies to reduce cognitive decline in AF.
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