Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study.
Thalia Shoshana FieldBob WeijsAntonio CurcioMichela GiustozziSaulius SudikasAnja KatholingChristopher WallenhorstJeffrey I WeitzAlexander T CohenCarlos MartinezPublished in: Thrombosis and haemostasis (2019)
Our findings support the hypothesis that AF is a distinct risk factor for dementia, independent of stroke/TIA and other vascular risk factors. In those without stroke/TIA, risk of dementia is increased only in those who are not on anticoagulation, suggesting anticoagulation is protective presumably through reduction of sub-clinical embolic events. Further prospective research is needed to better ascertain the role of anticoagulation amongst targeted therapeutic strategies to reduce cognitive decline in AF.
Keyphrases
- atrial fibrillation
- mild cognitive impairment
- cognitive decline
- oral anticoagulants
- left atrial
- catheter ablation
- left atrial appendage
- direct oral anticoagulants
- risk factors
- heart failure
- cognitive impairment
- percutaneous coronary intervention
- cardiovascular disease
- venous thromboembolism
- type diabetes
- brain injury
- coronary artery disease
- mitral valve
- drug delivery
- left ventricular
- subarachnoid hemorrhage