TGF-β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling.

Qingxuan WangChenchen ZhouXiaobing LiLinyi CaiJing ZouDemao ZhangJing XieWenli Lai

Published in: Cell proliferation (2018)

For the first time, these results revealed a vital role of TGF-β1 in cell-cell communication in chondrocytes via gap junction formation. We describe the regulatory mechanism, the involvement of TGF-β type I receptor and the nuclear translocation of Smad3/4.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
single cell
cell therapy
stem cells
extracellular matrix
signaling pathway
mesenchymal stem cells