A Rare Potential Pathogenic Variant in the BDNF Gene is Found in a Brazilian Patient with Severe Childhood-Onset Obesity.
Ana Carolina Proença da FonsecaGabriella de Medeiros AbreuLohanna PalhinhaVerônica Marques ZembrzuskiMário Campos JuniorJoão Régis Ivar CarneiroJosé Firmino Nogueira NetoFernanda Cristina C Mattos MagnoEliane Lopes RosadoClarissa Menezes Maya-MonteiroGiselda Maria Kalil de CabelloPedro Hernán Cabello AceroPatrícia Torres BozzaPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2021)
We observed that the common BDNF p.(Val66Met) variant has influenced waist circumference, HDL-cholesterol, and MCP1 levels. This polymorphism has also a protective effect on metabolic syndrome susceptibility. Additionally, we described for the first time a rare potentially pathogenic BDNF variant in a Brazilian patient with severe obesity and childhood-onset.
Keyphrases
- metabolic syndrome
- insulin resistance
- body mass index
- case report
- weight loss
- stress induced
- type diabetes
- weight gain
- high fat diet induced
- early onset
- uric acid
- body weight
- early life
- childhood cancer
- cardiovascular disease
- genome wide
- copy number
- gene expression
- physical activity
- drug induced
- risk assessment
- human health