Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies.
Karsten KleoVladimir M JovanovicAlexander ArndoldAnnika LehmannHedwig LammertErika BergHannah HarloffChristoph TreeseMichael HummelSeverin DaumPublished in: Journal of cancer research and clinical oncology (2022)
Although we could not identify discriminating target genes, our data suggest that molecular alterations are in general more prevalent in patients with AEG/AS belonging to the non-responding Becker group 3.
Keyphrases
- neoadjuvant chemotherapy
- genome wide identification
- locally advanced
- transcription factor
- copy number
- genome wide
- rectal cancer
- squamous cell carcinoma
- muscular dystrophy
- lymph node
- sentinel lymph node
- electronic health record
- radiation therapy
- cancer therapy
- big data
- single molecule
- duchenne muscular dystrophy
- dna methylation
- circulating tumor
- ultrasound guided
- data analysis
- early stage