In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine.
Wen-Sheng HuangGuann-Juh ChenTung-Han TsaiChen-Yi ChengChyng-Yann ShiueKuo-Hsing MaSkye Hsin-Hsien YehPublished in: EJNMMI research (2019)
The present results suggested that the long-lasting response to METH decreased the uptake of 4-[18F]-ADAM and varied regionally along with TH immunoreactivity. In addition, 4-[18F]ADAM PET could be used to detect serotonergic neuron loss and to evaluate the severity of serotonergic neurotoxicity of METH.