Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease.
Nicholas A StoweAjay P SinghBrian R BarnettSue Y YiPaloma C FrautschiAlbee MessingTracy L HagemannJohn Paul J YuPublished in: Magnetic resonance in medicine (2023)
We present the first application of NODDI to the study of AxD using a rat genetic model of AxD. Our analysis identifies alterations in NODDI and DTI measures to large white matter tracts and subcortical gray nuclei. We further identified genotype by sex interactions, suggesting a possible role for biological sex in the neuropathogenesis of AxD.