Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD.

Frédéric SoysouvanhDéborah RousseauStéphanie BonnafousManon BourinetAxelle StrazzullaStéphanie PatourauxJean MachowiakMarwin A FarrugiaAntonio IannelliAlbert TranRodolphe AntyCarmelo LuciPhilippe Gual

Published in: Obesity (Silver Spring, Md.) (2023)

Current findings highlight a critical role of SPP1 in the initiation of obesity-driven chronic inflammation by regulating accumulation and/or polarization of T cells. Early targeting of SPP1 could be beneficial for IR and MAFLD treatment.

Keyphrases

insulin resistance
adipose tissue
high fat diet
metabolic syndrome
high fat diet induced
skeletal muscle
type diabetes
polycystic ovary syndrome
oxidative stress
cancer therapy
weight gain
drug delivery
combination therapy
physical activity