Clinical validation of the Siemens quantitative SARS-CoV-2 spike IgG assay (sCOVG) reveals improved sensitivity and a good correlation with virus neutralization titers.

Christian IrsaraAlexander E EggerWolfgang ProkopManfred NairzLorin LoackerSabina SahanicAlex PizziniThomas SonnweberBarbara HolzerWolfgang MayerHarald SchennachJudith Loeffler-RaggRosa Bellmann-WeilerBoris HartmannIvan TancevskiGünter WeissChristoph J BinderMarkus AnlikerAndrea GriesmacherGregor Hoermann

Published in: Clinical chemistry and laboratory medicine (2021)

Performance characteristics of the sCOVG assay have been improved compared to the predecessor test COV2G. Quantitative SARS-CoV-2 S1-RBD IgG levels could be used as a surrogate for virus neutralization capacity. Further harmonization of antibody quantification might assist to monitor the humoral immune response after COVID-19 disease or vaccination.

Keyphrases

sars cov
immune response
respiratory syndrome coronavirus
high throughput
high resolution
coronavirus disease
toll like receptor
dendritic cells
disease virus