IFNα Augments Clinical Efficacy of Regulatory T-cell Depletion with Denileukin Diftitox in Ovarian Cancer.
Suzanne R ThibodeauxBrian B BarnettSrilakshmi PandeswaraShawna R WallVincent HurezVinh DaoLishi SunBenjamin J DanielMichael J BrumlikJustin DrerupÁlvaro PadrónTheresa L WhitesideIlona KryczekWeiping ZouTyler J CurielPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Treg depletion is clinically useful but unlikely alone to cure ovarian cancer. Rational treatment agent combinations can salvage clinical failure of Treg depletion alone, even when neither single agent provides meaningful clinical benefit.
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