A solid-state NMR method for characterization of pharmaceutical eutectics.
Chaithanya HareendranParth S ShaligramRajesh G GonnadeThalasseril G AjithkumarPublished in: Physical chemistry chemical physics : PCCP (2024)
Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.