A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission.

Zhe ChenJingxiong LuFan XiaoYishun HuangXuanjun Zhang Leilei Tian

Published in: Chemical communications (Cambridge, England) (2020)

A new DNA nanoprobe based on a Y-shape and pyrene-modified DNA self-assembly is developed to sensitively and specifically detect microRNA through a pyrene excimer-monomer switch. Exhibiting the capability of self-delivery and resistance to nuclease degradation, the nanoprobe has been successfully applied for microRNA imaging in live cells.

Keyphrases

induced apoptosis
circulating tumor
single molecule
cell free
cell cycle arrest
high resolution
living cells
oxidative stress
nucleic acid
signaling pathway
cell proliferation
photodynamic therapy