Evaluation of a novel 177 Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile.

Yongsheng LiuMaryam OroujeniYunqi LiaoAnzhelika VorobyevaVitalina BodenkoAnna OrlovaMark KonijnenbergMatilda CarlqvistElisabet WahlbergAnnika LofteniusFredrik Y FrejdVladimir Tolmachev

Published in: European journal of nuclear medicine and molecular imaging (2024)

Lu]Lu-PEP49989 demonstrated favourable biodistribution and a strong antitumour effect, which was further enhanced by co-treatment with trastuzumab.

Keyphrases

pet imaging

epidermal growth factor receptor

computed tomography

positron emission tomography