Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors.
Mariana Ferreira LealBen P HaynesEugene SchusterBelinda YeoMaria AfentakisLila ZabagloVera MartinsRichard BuusAndrew DodsonMaggie Chon U CheangIan E SmithLesley-Ann MartinMitch DowsettPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Ligand-independent ER signaling, as a result of ESR1 mutation or reduced ER dependence, identified after extended NAI therapy, can guide early selection of patients who would benefit from combination therapy.