Whole-Genome Transcriptomics of PBMC to Identify Biomarkers of Early Metabolic Risk in Apparently Healthy People with Overweight-Obesity and in Normal-Weight Subjects.

Andrea CostaInge van der SteltBàrbara ReynésJadwiga KoniecznaMiquel FiolJaap KeijerAndreu PalouDora RomagueraEvert M van SchothorstPaula Oliver

Published in: Molecular nutrition & food research (2022)

PBMC gene expression analysis of CXCL8 or a pool of DEGs may be used to identify early metabolic risk in an apparently healthy population regardless of their BMI, i.e., subjects with OW-OB or MONW phenotype and to apply adequate and personalized nutritional preventive strategies.

Keyphrases

weight gain
gene expression
weight loss
body mass index
physical activity
metabolic syndrome
dna methylation
insulin resistance
single cell
adipose tissue