Mesenchymal Stem Cells Genetically Modified by Lentivirus-Express Soluble TRAIL and Interleukin-12 Inhibit Growth and Reduced Metastasis-Relate Changes in Lymphoma Mice Model.
Adriana G Quiroz-ReyesCarlos A Gonzalez-VillarrealAlberto Y Limon-FloresPaulina Delgado-GonzalezHerminia G Martinez-RodriguezSalvador L Said-FernandezAdolfo Soto-DominguezAna M Rivas-EstillaJosé Francisco IslasJuan Francisco Molina de la GarzaElsa N Garza-TreviñoPublished in: Biomedicines (2023)
MSC expressing IL-12, is or combination with BM-MSC expressing sTRAIL represents an antitumor strategy for lymphoma tumors since they increase survival and reduce tumor development. However, the combination did not show significative additive effect. The localized application did not inhibit metastasis but reduced morphological alterations of tissue associated with liver metastasis.