Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy.
Xiaohui YuKexuan ChenYingzi MaTongjian BaiShunli ZhuDefang CaiXing ZhangKai WangYuanghua TianJiaojian WangPublished in: CNS neuroscience & therapeutics (2024)
Compared to pretreatment, the BEN in the posterior cerebellar lobe (PCL) significantly decreased and FC between the PCL and the right temporal pole (TP) significantly increased in MDD patients after treatment. Moreover, we found that these changes of BEN and FC were closely associated with genes' expression profiles involved in MAPK signaling pathway, GABAergic synapse, and dopaminergic synapse and were significantly correlated with the receptor/transporter density of 5-HT, norepinephrine, glutamate, etc. CONCLUSION: These findings suggest that loops in the cerebellum and TP are crucial for ECT regulation of mood and cognition, which provides new evidence for the antidepressant effects of ECT and the potential molecular mechanism leading to cognitive impairment.
Keyphrases
- functional connectivity
- resting state
- signaling pathway
- major depressive disorder
- cognitive impairment
- bipolar disorder
- end stage renal disease
- ejection fraction
- pi k akt
- newly diagnosed
- white matter
- prognostic factors
- oxidative stress
- multiple sclerosis
- dna methylation
- epithelial mesenchymal transition
- induced apoptosis
- gene expression
- mild cognitive impairment
- patient reported outcomes
- depressive symptoms
- endoplasmic reticulum stress
- cell proliferation
- brain injury
- human health
- bioinformatics analysis
- binding protein