Taken together, these findings firstly revealed that miR-27a-3p, as one of the main components of OGD-pretreated ADEVs, attenuated BBB destruction and improved neurological deficits following ICH by regulating endothelial ARHGAP25/Wnt/β-catenin axis. OGD-ADEVs might be a novel strategy for the treatment of ICH. this study implicates that EVs from OGD pre-stimulated astrocytes.
Keyphrases
- cell proliferation
- stem cells
- blood brain barrier
- epithelial mesenchymal transition
- mesenchymal stem cells
- endothelial cells
- traumatic brain injury
- high glucose
- brain injury
- blood glucose
- metabolic syndrome
- drug induced
- blood pressure
- oxidative stress
- adipose tissue
- combination therapy
- cerebral ischemia
- smoking cessation
- replacement therapy
- weight loss