Development and Optimization of a Target Engagement Model of Brain IDO Inhibition for Alzheimer's Disease.

Kurt R StoverPaul M StaffordAndreea C DamianJagadeesh P PasangulapatiJake Goodwin-TindallLucía M López VásquezSanghyun LeeSeung-Pil YangMark A ReedChristopher J BardenDonald F Weaver

Published in: Current Alzheimer research (2024)

This LPS-based model of IDO1 target engagement is a useful tool that can be used in the development of brain penetrant IDO1 inhibitors for AD. A limitation of the present study is the lack of quantification of potential clinically relevant biomarkers in this model, which could be addressed in future studies.

Keyphrases

social media
white matter
resting state
risk assessment
current status
human health