Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2'-deoxy-2'-b-fluoro-4'-azidocytidine)-induced inhibition of Dalton's lymphoma growth and proliferation.
Naveen KumarSanjeev KumarAlok ShuklaSanjay KumarRishi Kant SinghIlya UlasovSandeep KumarAnand Kumar PatelLokesh YadavRuchi Tiwarinull RachanaShivashish Priyadarshi Mohantanull KaushalendraVikram DeluArbind AcharyaPublished in: Discover. Oncology (2024)
FNC represents an efficient and targeted treatment strategy against T-cell lymphoma. FNC's proficient ability to induce apoptosis through ROS generation and MMP reduction makes it a promising candidate for developing newer and more effective anticancer therapies. Continued research could unveil FNC's potential role in designing a better therapeutic approach against NHL.
Keyphrases
- oxidative stress
- cell death
- diabetic rats
- high glucose
- dna damage
- signaling pathway
- diffuse large b cell lymphoma
- endoplasmic reticulum stress
- positron emission tomography
- cell cycle arrest
- reactive oxygen species
- cancer therapy
- computed tomography
- drug induced
- endothelial cells
- combination therapy
- cell proliferation
- stress induced
- smoking cessation