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KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma.

Sarah M ChoiAleodor A AndeaMin WangAmir BehdadLina ShaoYanming ZhangXinyan LuDavid DittmannJuan CastroYi-Hua ChenJuehua Gao
Published in: Diagnostic pathology (2018)
This report highlights genetic alterations, in particular an acquired somatic KRAS mutation, that may occur during transdifferentiation, with additional significance of KRAS mutation as a possible therapeutic target in cases which otherwise would have limited treatment options.
Keyphrases
  • low grade
  • wild type
  • high grade
  • genome wide