Visceral adiposity and systemic inflammation in the obesity paradox in patients with unresectable or metastatic melanoma undergoing immune checkpoint inhibitor therapy: a retrospective cohort study.

Ji Hyun Lee Sujin Hyung Jeeyun Lee Sang-Hee Choi

Published in: Journal for immunotherapy of cancer (2022)

Visceral adiposity and systemic inflammation are significant prognostic factors in patients with unresectable or metastatic melanoma receiving immune checkpoint inhibitors. The prognostic impact of visceral adiposity is dependent on systemic inflammation status.

Keyphrases

insulin resistance
prognostic factors
metabolic syndrome
adipose tissue
high fat diet induced
skeletal muscle
type diabetes
locally advanced
weight gain
liver metastases
squamous cell carcinoma
stem cells
rectal cancer
weight loss
mesenchymal stem cells
physical activity