Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects.
Ya-Hui ChanKuo-Ning HoYu-Chieh LeeMeng-Jung ChouWei-Zhen LewHaw-Ming HuangPin-Chuang LaiSheng-Wei FengPublished in: Stem cell research & therapy (2022)
These results suggest that melatonin promotes the proliferation and osteogenic differentiation of DPSCs by regulating COX-2/NF-κB and p38/ERK MAPK signaling pathways. Preconditioning DPSCs with melatonin before transplantation can efficiently enhance MSCs function and regenerative capacities.
Keyphrases
- signaling pathway
- bone regeneration
- mesenchymal stem cells
- pi k akt
- umbilical cord
- cell therapy
- induced apoptosis
- epithelial mesenchymal transition
- bone marrow
- stem cells
- cell proliferation
- tissue engineering
- inflammatory response
- brain injury
- postmenopausal women
- endoplasmic reticulum stress
- bone loss
- nuclear factor