Type 2 diabetes affects bone cells precursors and bone turnover.
Francesca SassiIlaria BuondonnoChiara LuppiElena SpertinoEmanuela StrattaMarco Di StefanoMarco RavazzoliGianluca IsaiaMarina TrentoPietro PasseraMassimo PortaGiovanni Carlo IsaiaMassimiliano MassaiaPublished in: BMC endocrine disorders (2018)
Patients with T2DM have more immature bone cells precursors, with increased number of osteoclasts and decreased osteoblasts, confirming low bone turnover and reduced cytokines such as RANKL and DKK-1. BMD and TBS are not significantly altered in T2DM although, in contrast with other studies, this may be due to the match of patients and controls for BMI rather than age.
Keyphrases
- bone mineral density
- bone loss
- induced apoptosis
- postmenopausal women
- type diabetes
- soft tissue
- cell cycle arrest
- body composition
- end stage renal disease
- bone regeneration
- glycemic control
- newly diagnosed
- magnetic resonance
- ejection fraction
- body mass index
- chronic kidney disease
- endoplasmic reticulum stress
- signaling pathway
- insulin resistance
- cell death
- magnetic resonance imaging
- prognostic factors
- computed tomography
- metabolic syndrome
- cell proliferation
- adipose tissue