Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.

Nicholas KingSoledad Garcia-MartinezEider AlcarazAlba GrisalenaRubin LubomirovRaquel AltaresCarlos Fernandez-TeruelAndrés M FranceschPablo M AvilésSalvador Fudio

Published in: PloS one (2023)

These UPLC-MS/MS methods enable the rapid and sensitive quantification of lurbinectedin and its main metabolites in clinical samples.

Keyphrases

ms ms
high resolution
liquid chromatography tandem mass spectrometry
solid phase extraction
molecularly imprinted
high performance liquid chromatography
loop mediated isothermal amplification