Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.
Jin San LeeHyejoo LeeSeongbeom ParkYeongsim ChoeYu Hyun ParkBo Kyoung CheonAlice HahnRik OssenkoppeleHee Jin KimSeonwoo KimHeejin YooHyemin JangSoo Hyun ChoSeung Joo KimJun Pyo KimYoung Hee JungKey-Chung ParkCharles DeCarliMichael W WeinerDuk L NaSang Won SeoPublished in: Neurology (2020)
Our findings suggest that APOE ε2 is distinctly associated with Aβ deposition in patients with SVCI and those with ADCI. Our findings further suggest that there is a distinctive subgroup of Aβ-positive APOE ε2 carriers with SVCI among patients with cognitive impairment.