Safety and tolerability of cryocompression as a method of enhanced limb hypothermia to reduce taxane-induced peripheral neuropathy.
Aishwarya BandlaStacey TanNesaretnam Barr KumarakulasingheYiqing HuangSally AngGayathiri MagarajahZarinah HairomJoline Si Jing LimAlvin WongGloria ChanNatalie NgoiEmily AngYee Mei LeeAmanda ChanSoo-Chin LeeNitish ThakorEinar Wilder-SmithRaghav SundarPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2019)
When compared to continuous-flow cooling, cryocompression permitted delivery of lower temperatures with similar tolerability. The lower skin surface temperatures achieved potentially lead to improved efficacy in neurotoxicity amelioration. Larger studies investigating cryocompression are required to validate these findings.