Genetic profiling of human bone marrow and adipose tissue-derived mesenchymal stem cells reveals differences in osteogenic signaling mediated by graphene.
Amber F MacDonaldRuby D TrotterChristopher D GriffinAustin J BowSteven D NewbyWilliam J KingLisa L AmelseThomas J MasiShawn E BourdoMadhu S DharPublished in: Journal of nanobiotechnology (2021)
Overall, this study shows that graphene genetically supports differentiation of both AD-MSCs and BM-MSCs but may involve different signaling mechanisms to achieve osteogenesis. Data further demonstrates the lack of aberrant signaling due to cell-graphene interaction, strengthening the application of specific form and concentration of graphene nanoparticles in bone tissue engineering.
Keyphrases
- mesenchymal stem cells
- bone marrow
- adipose tissue
- tissue engineering
- walled carbon nanotubes
- room temperature
- carbon nanotubes
- single cell
- umbilical cord
- insulin resistance
- cell therapy
- stem cells
- genome wide
- high fat diet
- metabolic syndrome
- machine learning
- copy number
- bone regeneration
- skeletal muscle
- induced pluripotent stem cells
- dna methylation
- artificial intelligence