Ti(III)-Catalyzed Anti-Markovnikov Reduction of Epoxides with Borohydride.

Published in: Organic letters (2024)

We have developed a Ti catalyst that carries out the anti-Markovnikov reduction of a wide range of epoxides; [BH 4 ] - is used as both the electron and the hydrogen atom source. It requires only mild conditions and accommodates a broad range of epoxide substrates. The Ti catalyst is readily available and is environmentally friendly.

Keyphrases

room temperature
ionic liquid
visible light
reduced graphene oxide
highly efficient
metal organic framework
electron transfer
low cost