Tenofovir disoproxil fumarate mediates neuronal injury by inducing neurotoxicity.

Xiaotian YangJuanmei ZhangYanhong ChengMengmeng CuiZhixiong JiangChunhui FanJiaxing ChenLixia QiHongliang LiuDengke Bao

Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2023)

Our results showed that TDF treatment significantly induced cell viability and induced apoptosis of SH-SY5Y cells and primary neuronal cells. Furthermore, the ROS levels and MDA productions were significantly up-regulated in nerve cells treated with TDF. CONCLUSION: Our findings indicated that TDF may induce neuronal cell apoptosis through increasing the intracellular ROS and the expression level of caspase-3, which may be related to the increasing prevalence of HAND.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell cycle arrest
cell death
dna damage
risk factors
pi k akt
breast cancer cells
long non coding rna
antiretroviral therapy
replacement therapy