Association of HLA polymorphisms and acetaminophen-related Steven-Johnson syndrome with severe ocular complications in Thai population.

Passara Jongkhajornpong Mayumi UetaKaevalin LekhanontVilavun PuangsricharernPinnita PrabhasawatPatchima ChantarenPhattrawan PisuchpenShigeru Kinoshita

Published in: The British journal of ophthalmology (2020)

HLA-B*44:03 was strongly associated with acetaminophen-related SJS/TEN patients who developed SOC in Thai population. In addition, we also found moderate to strong associations with HLA-A*33:03 and HLA-C*07:01 suggesting their potential roles in the pathogenesis of SOC in acetaminophen-related SJS/TEN.

Keyphrases

liver injury
drug induced
risk factors
risk assessment
optical coherence tomography