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Facile Synthesis of π-Conjugated Quinazoline-Substituted Ethenes from 2-Ethynylanilines and Benzonitriles under Transition-Metal-Free Conditions.

Xu WangJiawei LiYubing HuangJiayi ZhuRongrong HuWanqing WuHuan-Feng Jiang
Published in: The Journal of organic chemistry (2018)
A new transition-metal-free version for the synthesis of π-conjugated quinazoline-substituted ethene derivatives from readily available starting materials has been developed. Quinazoline-substituted ethenes were obtained in moderate to high yields with completely Z-selectivity, and the resulting quinazoline-substituted ethenes show typical aggregation-induced emission (AIE) properties.
Keyphrases
  • molecular docking
  • photodynamic therapy
  • molecular dynamics simulations
  • high intensity
  • living cells
  • psychometric properties
  • single molecule
  • solid state