Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive Bioinformatics Analysis.
Ming ZhaiPeipei LuanYefei ShiBo LiJianhua KangFan HuMingjie LiLei DuDonglei ZhouWei-Xia JianWenhui PengPublished in: International journal of endocrinology (2021)
This article revealed that CSF1R, C1QC, and TYROBP were potential hub genes associated with immune cells' infiltration and the function of proinflammation, especially adipose tissue macrophages, in the progression of obesity-induced diabetes or insulin-resistance.
Keyphrases
- insulin resistance
- adipose tissue
- bioinformatics analysis
- high fat diet
- obese patients
- type diabetes
- metabolic syndrome
- high fat diet induced
- polycystic ovary syndrome
- skeletal muscle
- bariatric surgery
- high glucose
- diabetic rats
- glycemic control
- cardiovascular disease
- drug induced
- gastric bypass
- physical activity
- weight loss
- climate change
- single cell
- endothelial cells
- weight gain