Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study.
Angelos SharobeamLongting LinChristina LamCarlos Garcia EsperonYash GawarikarRonak PatelMatthew Lee-ArcherAndrew WongMichael RoizmanAmanda GilliganAndrew LeeKee Meng TanSusan DayChristopher LeviStephen M DavisMark ParsonsBernard YanPublished in: Stroke and vascular neurology (2023)
Commencing anticoagulation <4 days after stroke or TIA is associated with fewer ischaemic lesions at 1 month in AF patients. There is no increased rate of haemorrhage with early anticoagulation. These results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated with AF might be safe, but randomised controlled studies are needed to inform clinical practice.
Keyphrases
- atrial fibrillation
- oral anticoagulants
- left atrial
- catheter ablation
- left atrial appendage
- direct oral anticoagulants
- heart failure
- clinical practice
- venous thromboembolism
- end stage renal disease
- ejection fraction
- newly diagnosed
- liver failure
- study protocol
- prognostic factors
- subarachnoid hemorrhage
- respiratory failure
- intensive care unit
- mitral valve
- case control
- mechanical ventilation
- aortic dissection