Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.
Cho Rong HongSunali Y MehtaH D Sarath LiyanageSarah P McManawayHo H LeeJagdish K JaiswalGib BogleMoana TercelFrederik B PruijnWilliam R WilsonKevin O HicksPublished in: Cancer chemotherapy and pharmacology (2021)
The nitroCBI HAP SN30548 generates a highly efficient bystander effect through local diffusion of its active metabolite in tumour tissue.