Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells.
Thitima PewklangKantapat ChansaenpakRung-Yi LaiParinya NoisaAnyanee KamkaewPublished in: RSC advances (2019)
AZB-IMC 2 was developed as a COX-2 specific probe that exhibited a brighter fluorescence signal in cancer cells that overexpress COX-2 compared to normal cells. Oxidative stress agent-treated inflamed cell lines inducing high COX-2 levels revealed an enhanced fluorescence signal. Inhibitory studies showed a markedly reduced fluorescence intensity in cancer cells. The results suggested that AZB-IMC 2 could be developed as a promising molecular tool for imaging guiding during surgery.
Keyphrases
- single molecule
- living cells
- induced apoptosis
- oxidative stress
- energy transfer
- quantum dots
- minimally invasive
- high resolution
- fluorescent probe
- endoplasmic reticulum stress
- signaling pathway
- single cell
- high intensity
- ischemia reperfusion injury
- nitric oxide synthase
- mass spectrometry
- diabetic rats
- newly diagnosed
- cell proliferation
- surgical site infection
- percutaneous coronary intervention