A somatic view of the genomic impact of mitochondrial endosymbiosis.

Published in: PLoS biology (2024)

The endosymbiosis of mitochondrial ancestors resulted in the transfer of genetic material on an evolutionary scale for eukaryotic species. A new study in PLOS Biology expands this to the genome of somatic cells within individuals and highlights its correlation with aging and disease.

Keyphrases

copy number
genome wide
oxidative stress
induced apoptosis
cell cycle arrest
dna methylation
gene expression
endoplasmic reticulum stress
cell death