Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization.

Maika S DeffieuCamille M H ClémentCristina M DorobantuEmma PartiotYonis BareOrestis FaklarisBenjamin RivièreNilda Vanesa Ayala-NunezThomas F BaumertPhilippe RondéYves MélyVincent LucanskyRaphaël Gaudin

Published in: Hepatology (Baltimore, Md.) (2022)

Together, our data provide robust evidence that HCV particles interact with OCLN away from TJs and shed mechanistic insights regarding the manipulation of transmembrane receptor localization by extracellular virus particles.

Keyphrases

hepatitis c virus
human immunodeficiency virus
blood brain barrier
electronic health record
single molecule
liver injury
machine learning
binding protein
drug induced
deep learning