Mass Production of Rg1-Loaded Small Extracellular Vesicles Using a 3D Bioreactor System for Enhanced Cardioprotective Efficacy of Doxorubicin-Induced Cardiotoxicity.
Yunfeng DiShuang ZhaoHuilan FanWei LiGuangjian JiangYong WangChun LiWei WangJingyu WangPublished in: Pharmaceutics (2024)
The 3D culture system scaled up the production of sEVs, which facilitated the Rg1 delivery and attenuated cardiomyocyte apoptosis, suggesting a potential treatment of DOX-induced cardiotoxicity.