Monitoring the tacrolimus concentration in peripheral blood mononuclear cells of kidney transplant recipients.
Marith I FranckeDennis A HesselinkYi LiBirgit C P KochLucia E A de WitRon H N van SchaikLin YangCarla C BaanTeun van GelderBrenda C M de WinterPublished in: British journal of clinical pharmacology (2020)
The correlation between [Tac]blood and [Tac]cells is poor. Age, albumin and haematocrit correlate with the [Tac]cells /[Tac]blood ratio, whereas genetic variation in ABCB1, CYP3A4 and CYP3A5 do not. Neither [Tac]blood nor [Tac]cells correlated with clinical outcomes.