PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages.

Yukiko YamaguchiJackson GibsonKevin OuLupita S LopezRachel H NgNeena LeggettVanessa D JonssonJelani C ZarifPeter P LeeXiuli WangCatalina MartinezTanya Barauskas DorffStephen J FormanSaul J Priceman

Published in: Journal for immunotherapy of cancer (2022)

This study reveals an alternative mechanism by which the combination of CAR T cells and immune checkpoint blockade modulates the immune landscape of solid tumors to enhance therapeutic efficacy of CAR T cells.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
immune response
dendritic cells
cell therapy
oxidative stress
nk cells