circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis.

Chonghui HuRenpeng XiaXiang ZhangTingting LiYuancheng YeGuolin LiRihua HeZhihua LiQing LinShangyou ZhengRufu Chen

Published in: Molecular cancer (2022)

The circFARP1/CAV1/miR-660-3p/LIF axis is critical for CAF-induced GEM resistance in PDAC. Hence, circFARP1 may be a potential therapeutic target for PDAC.

Keyphrases

high glucose
cell proliferation
oxidative stress
endothelial cells
rectal cancer