Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women.
De-Min DuanJing-Yi JhangSemon WuMing-Sheng TengLung-An HsuYu-Lin KoPublished in: Molecular genetics & genomic medicine (2020)
The LEP polymorphisms are independently associated with leptin levels in Taiwanese obese women. Further, the genetic determinants for leptin levels may be different between obese and nonobese, and in different sex individuals. The obesity status and female sex may exert modification effect on transcription of LEP, particularly in obese women.