Controlled delivery of ciprofloxacin and ivacaftor via sinus stent in a preclinical model of Pseudomonas sinusitis.

Dong-Jin LimJustin P McCormickDaniel SkinnerShaoyan ZhangJeffrey B ElderJohn G McLemoreMark AllenJohn Martin WestJessica W GraysonSteven M RoweBradford A WoodworthDo-Yeon Cho

Published in: International forum of allergy & rhinology (2019)

The CISS had robust clinical efficacy in treating P aeruginosa rabbit sinusitis. The innovative design of double-layered drug coating on the surface of the biodegradable stent may provide therapeutic advantages over current treatment strategies for P aeruginosa sinusitis.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
drug delivery
biofilm formation
stem cells
cell therapy
escherichia coli
mesenchymal stem cells
gold nanoparticles
plant growth