Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2-VEGFA axis.

Makoto NatsumeTakaya ShimuraHiroyasu IwasakiYusuke OkudaKazuki HayashiSatoru TakahashiHiromi Kataoka

Published in: British journal of cancer (2020)

Omental adipocytes trigger GC cells to an aggressive phenotype through CXCL2 secretion, which induces angiogenesis followed by cell growth and peritoneal metastasis.

Keyphrases

adipose tissue
induced apoptosis
cell cycle arrest
endothelial cells
vascular endothelial growth factor
endoplasmic reticulum stress
high fat diet induced
type diabetes
signaling pathway
cell death
oxidative stress
skeletal muscle
insulin resistance
wound healing
mass spectrometry
simultaneous determination