The safe use of metformin in heart failure patients both with and without T2DM: a cross-sectional and longitudinal study.
G ChowdhuryJane Ellen CarlandS KumarN OlsenGarry G GrahamG KumarasingheC S HaywardJerry R GreenfieldP MacdonaldRichard Osborne DaySophie Lena StockerPublished in: British journal of clinical pharmacology (2023)
We observed no unsafe plasma lactate concentrations in patients with heart failure treated with metformin. Metformin exposure did not influence plasma lactate concentrations; however, NYHA class and sex did. The pharmacokinetics of metformin in heart failure patients are similar irrespective of T2DM. These findings may support the safe use of metformin in heart failure patients with and without T2DM.