Hypoxia-Reoxygenation Couples 3βHSD1 Enzyme and Cofactor Upregulation to Facilitate Androgen Biosynthesis and Hormone Therapy Resistance in Prostate Cancer.
Liang QinYoon-Mi ChungMichael BerkBryan D NaelitzZiqi ZhuEric E KleinAbhishek A ChakrabortyNima SharifiPublished in: Cancer research (2022)
Hypoxia followed by reoxygenation in prostate cancer drives androgen deprivation therapy resistance via increasing the rate-limiting enzyme and cofactors for androgen synthesis, revealing HIF2α as a therapeutic target to subvert resistance.