The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.

Xin SunVijesh VaghjianiW Samantha N JayasekaraJason E CainJustin C St John

Published in: Clinical epigenetics (2018)

Our findings highlight the influences that the nuclear and mitochondrial genomes have in setting mtDNA methylation patterns to regulate mtDNA copy number in tumorigenesis. They have important implications for assessing global DNA methylation patterns in tumorigenesis and the availability of mtDNA template for mtDNA replication.

Keyphrases

copy number
dna methylation
genome wide
mitochondrial dna
gene expression
oxidative stress
high resolution
molecularly imprinted
solid phase extraction