Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression.

Chuying WangFeng BaiLi-Han ZhangAlexandria ScottEnxiao LiXin-Hai Pei

Published in: Breast cancer research : BCR (2018)

This study reveals for the first time that estrogen promotes BRCA1-deficient tumor initiation and progression by stimulation of cell proliferation and activation of EMT, which are dependent on AKT activation and independent of ER.

Keyphrases

estrogen receptor
cell proliferation
epithelial mesenchymal transition
signaling pathway
cell cycle
pi k akt