A new aggressive xenograft model of human colon cancer using cancer-associated fibroblasts.
Ester Fernando-MacíasMaria Teresa Fernández-GarcíaEva García-PérezBelén Porrero GuerreroCamilo López-ArévaloRaquel Rodríguez-UríaSandra Sanz-NavarroJosé Fernando Vázquez-VillaMaría Carmen Muñíz-SalgueiroLaura Suárez-FernándezJosé A GalvánClara Barneo-CaragolMarcos García-OcañaJuan R de Los ToyosLuis Barneo-SerraPublished in: PeerJ (2020)
Our experiments demonstrate that cultured CAFs have a higher growth than NF and that when human CAFs are associated to human tumor cells, larger tumors with liver and lung metastases are generated than if only colon cancer cells with/without NF are transplanted. This emphasizes the importance of the tumor stroma, and especially the CAFs, in the development of cancer.